Call 2014

The Call 2014, thanks to the contribution of the Ice Bucket Challenge, funded 15 projects of scientific excellence. The projects have been selected following a thorough evaluation process in peer review of the proposals submitted.

10 of the 15 projects funded are of basic research, 3 are of translational research and 2 projects are of clinical research, for a total value of 2.137 million euro.

Two different types of projects participated to the 2014 Call:

  • Full Grants, ie “research projects with a solid background, preliminary data already available and research activities already underway in the area of basic research, translational research or clinical research”. Full Grant Proposals could have a maximum duration of 36 months.and the opportunity to conduct research in scientific collaboration with other partners. It was recommended not to exceed the request of a total of € 300,000 as contribution from AriSLA.

The thematic areas of Full Grant projects were:

  • Clinical treatment;
  • Multi-disciplinary and innovative approaches;
  • Markers of disease onset and progression;
  • Novel disease models;
  • Pathological pathways and mechanisms translationally oriented.
  • Pilot Grants, ie “projects with high innovative and original research hypothesis, though with preliminary data to be consolidated or not available, in the area of basic or translational research. Applications were intended to collect or strengthen preliminary data for subsequent larger scale funding. Pilot Grant Proposals could be supported with a contribution up to € 60,000 over maximum 12 months.
    This fund may cover the whole or part of the remuneration of the Principal Investigator, if, at the moment of the contract signature with AriSLA, he did not held any employment contract and did not reach 40 years of age. This type of research projects had to be managed by a single proponent.

The thematic areas of Pilot Grant projects are

  • Drug discovery;
  • Markers of disease onset and progression;
  • Novel disease models;
  • Novel pathological pathways and mechanisms.

For the selection of project proposals have been identified different evaluation criteria for the two types of grant (Pilot Grants and Full Grants). In any case, for both types of projects, the requirements were “Innovation and priorities over the state-of-the-art science, scientific interest and strong impact on the understanding and treatment of disease”.

LETTER OF INTENT (LoI) SUBMISSION

AREA FULL GRANTS LoI n (euro) PILOT GRANTS LoI n (euro) OVERALL VALUE n  (euro)
Basic  Research 14 (3.186.000) 62 (3.474.000) 76 (6.660.000)
Translational Research  21 (5.241.017) 26 (1.443.150) 47 (6.684.167)
Clinical Research  10 (2.406.000) 10 (2.406.000)
TOTAL 45 (10.833.017)
88 (4.917.150) 133 (15.750.167)

FULL PROPOSAL (FP) SUBMISSION

AREA FULL GRANTS FP n (euro) PILOT GRANTS FP n (euro) OVERAL FP VALUE n (euro)
Basic  Research 6 (1.539.999,1) 12 (680.850) 18 (2.220.849,1)
Translational Research   8(1.973.593)  4 (233.000) 12 (2.206.593)
Clinical  Research  5(1.100.880)  5 (1.100.880)
TOTAL  19 (4.614.472,1)
16 (913.850) 35 (5.528.322,1)

 WINNER PROJECTS 2014

To view the press release and the short version of the projects please visit news and press releases section.

 FULL GRANT

Nr Title PI Value (euro) Type of research Duration (months) PDF
1 ARCI, RNA circuitries in Amiotrophic Lateral Sclerosis pathogenesis Irene Bozzoni, Univ. degli Studi di Roma “La Sapienza” 240.000,00 Basic, Full Grant 36 icona_pdf
2 CARDI NALS, Cardiovascular Neural Regulation In Amyotrophic Lateral Sclerosis Laura Dalla Vecchia, Fondazione Salvatore Maugeri IRCCS, Milano 121.00,00  Clinical, Full Grant 36 icona_pdf
3 CHRONOS, Chronic and Sporadic Mechanisms of TDP-43 Dysfunction Fabian Feiguin, International Centre For Genetic Engineering And Biotechnology (ICGEB), Trieste 170.100,00 Basic, Full Grant 36 icona_pdf
4 CONNECTALS, Network degeneration in motor neuron diseases (MND): a study of the structural and functional connectomes in Amyotrophic Lateral Sclerosis and other MND Massimo Filippi, Fondazione Centro San Raffaele, Milano  300.000,00 Clinical, Full Grant 36 icona_pdf
5 GRANULOPATHY, VCP and autophagolysosomal pathway: guardians of proteostasis and stress granule dynamics. Unraveling their applications in ALS Serena Carra, Univ. degli Studi di Modena e Reggio Emilia  299.585,00 Basic, Full Grant  36  icona_pdf
6 PATH-FOR-ALS, P2X7 as a target for Amyotrophic Lateral Sclerosis  Cinzia Volontè, Istituto di Biologia Cellulare e Neurobiologia, CNR, Roma 147.000,00  Translational, Full Grant 24 icona_pdf
7 GF_ALS, Genetic engineering to produce new proteins for the protection of MN in ALS Ermanno Gherardi, Univ. degli Studi di Pavia 172.370,00   Translational, Pilot Grant 24 icona_pdf
 8 smallRNALS, The role of dysregulation of small RNAs and proteomic analysis of patient-derived induced pluripotent stem cells Stefania Corti, Univ. degli Studi di Milano  300.00,00 Basic, Full Grant  36 icona_pdf

PILOT GRANT

Nr Title PI Value (euro) Type of research Duration (months) PDF
1 ALSHDCA1, HDAC-1 TDP-43 interaction: implication for ALS Claudia Crosio, Univ. degli Studi di Sassari 60.000,00 Basic, Pilot Grant 12 icona_pdf
2 CONSLA, Setting Of A new pre-Conditioning Model for Amyotrophic Lateral Sclerosis Giuseppe Pignataro, Univ. degli Studi di Napoli “Federico II” 44.992,50 Basic, Pilot Grant 12 icona_pdf
3 DC-ALS, Activation state and Functionality of Dendritic cells from pheripheral blood of ALS patients Francesca Granucci, Univ. degli Studi di Milano-Bicocca 50.000,00 Basic, Pilot Grant 12 icona_pdf
4 EX ALTA, EXploring the peripheral nervous system path to unravel Amyotrophic LaTerAl sclerosis Angelo Quattrini, Fondazione Centro San Raffaele  56.000,00 Translational, Pilot Grant 12 icona_pdf
5 EpiALS    Study of the role of epigenetic regulators in the pathogenesis of ALS Camilla Bernardini, Univ. Cattolica del Sacro Cuore  60.000,00 Basic, Pilot Grant  36  icona_pdf
6 FUSMALS, Functional Interaction of FUS with SMN as A Common Pathogenic Pathway For Motor Neuron Diseases Mauro Cozzolino, Istituto di Farmacologia Traslazionale, CNR, Roma 59.955,00 Basic, Full Grant 12 icona_pdf
7 MAMMALS, MiRNAs as Microglia Modifiers for ALS Chiara Parisi, Istituto di Biologia Cellulare e Neurobiologia, CNR, Roma 56.000,00 Basic, Pilot Grant 12 icona_pdf